PGAM5-KEAP1-NRF2 Complex: Potential Drug Targets (P24881)

Target Name: PGAM5-KEAP1-NRF2 Complex

NCBI ID: P24881

PGAM5-KEAP1-NRF2 Complex

Other Name(s): None

PGAM5-KEAP1-NRF2 Complex: Potential Drug Targets

The PGAM5-KEAP1-NRF2 complex is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is composed of three subunits: PGAM5, KEAP1, and NRF2. PGAM5 and KEAP1 are both part of the superfamily of transmembrane proteins known as the PSD family, while NRF2 is a nuclear factor of transcription (NFAT) gene.

The PGAM5-KEAP1-NRF2 complex plays a crucial role in the regulation of various cellular processes in the body, including cell signaling, inflammation, and stress responses. It is involved in the development and maintenance of the blood-brain barrier, which is a barrier that separates the brain from the blood and lymphatic system, and allows certain substances to enter the brain.

The PGAM5-KEAP1-NRF2 complex is also involved in the regulation of pain perception and neuroinflammation. Studies have shown that the complex is involved in the neurotransmission of pain signals and in the regulation of inflammation in response to injury or infection.

In addition to its role in the regulation of pain and inflammation, the PGAM5-KEAP1-NRF2 complex is also a potential drug target. Researchers have identified several potential small molecules that can inhibit the activity of the complex, and these molecules have been shown to have therapeutic potential in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising small molecules that can inhibit the activity of the PGAM5-KEAP1-NRF2 complex is a compound called P381. P381 is a potent inhibitor of the complex, and has been shown to have therapeutic potential in a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Another small molecule that has been shown to inhibit the activity of the PGAM5-KEAP1-NRF2 complex is called Nrf2. Nrf2 is a transcription factor that is involved in the regulation of gene expression, and has been shown to play a role in the regulation of the PGAM5-KEAP1-NRF2 complex.

In conclusion, the PGAM5-KEAP1-NRF2 complex is a protein that is involved in a variety of cellular processes in the body, including cell signaling, inflammation, and stress responses. It is also a potential drug target, and several small molecules have been shown to inhibit its activity. Further research is needed to fully understand the role of the PGAM5-KEAP1-NRF2 complex in the regulation of various cellular processes in the body, and to identify potential small molecules that can be used to treat neurodegenerative diseases.

Protein Name: PGAM5-KEAP1-NRF2 Complex

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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